Joint penetration of augmentin
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Antibiotic penetration of synovial fluid in infected and normal knee joints. - PubMed - NCBI
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We present the first evaluation of the bone penetration of a beta-lactam by population . in combination with mg clavulanic acid (Augmentin; GlaxoSmithKline, the femoral neck and the subsequent implantation of the prosthetic hip joint.
Description:Scale terms were included to describe the equilibrium concentration ratios between cancellous bone and serum Fcancellous and between cortical bone and serum Fcortical. Population pharmacokinetic PK modeling offers the advantage that it can fit the full time course of the bone and serum concentrations on the basis of the data for all patients simultaneously. Both analyses were in the negative mode. The patients were diagnosed with coxarthosis and had no inflammation of the joints. Twenty patients 9 males, 11 females who were scheduled to undergo total hip replacement participated in this controlled clinical study. The differential equations for clavulanic acid can be obtained from the above equations by setting CLic equal to 0.
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